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hct15 cells  (Korean Cell Line Bank)

 
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    Korean Cell Line Bank hct15 cells
    Hct15 Cells, supplied by Korean Cell Line Bank, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hct15+cells/cells+hct15/pm41857570-71-8-17
    Average 86 stars, based on 1 article reviews
    hct15 cells - by Bioz Stars, 2026-10
    86/100 stars

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    Related Articles

    Knockdown:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Expressing:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Western Blot:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Quantitative RT-PCR:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Control:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Transfection:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    CCK-8 Assay:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Incubation:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Staining:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Diff-Quik:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Extraction:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Cell Culture:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Purification:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Phospho-proteomics:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Alternative Splicing:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Produced:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Fluorescence:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Reverse Transcription Polymerase Chain Reaction:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Activation Assay:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea

    Negative Control:

    Article Title: 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53.
    Article Snippet: Department of Bio and Chemical Engineering, Hongik University, Sejong, South Korea Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea Division of Biotechnology, Jeonbuk National University, Iksan, South Korea Department of Biological Science, Gachon University, Seongnam, South Korea Department of Biological Engineering, Konkuk University, Seoul, South Korea Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea Department of Medicine, College of Medicine, Seoul National University, Seoul, South Korea Department of Pathology, Jeonbuk National University Medical School, Jeonju, South Korea Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju, South Korea Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea



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    Image Search Results


    Urolithin A suppresses CRC cell proliferation and enhances T-cell activation. (A) Dose–response curves of UA in HCT15, HCT116, MC38, NCM460 and MCEC cells at 48 h and 72 h, with corresponding IC 50 values. The selectivity index (SI = IC 50 normal / IC 50 cancer) is shown for each cell line; (B-C) Effects of increasing concentrations of UA on the viability of CTLL-2 cells and human CD8 + T cells (hCD8 + T) at 48 h; (D) Schematic illustration of T-cell and tumor cell co-culture in the presence of UA; (E-G) Cell viability assays demonstrating that combined treatment with UA (20 or 25 µM) and T cells more effectively suppresses the proliferation of HCT15, HCT116, and MC38 cells compared with UA or T-cell treatment alone; (H) Western blot analysis showing the effects of UA (15, 20 or 25 µM) on the phosphorylation levels of AKT and mTOR in HCT15, HCT116, and MC38 cells, as well as the regulation of p-FOXO1, TCF1, GZMB, and p-AKT in hCD8⁺ T cells and CTLL-2 cells. P < 0.05 was considered statistically significant (* P < 0.05, ** P < 0.01, *** P < 0.001).

    Journal: Scientific Reports

    Article Title: Urolithin A blocks colorectal cancer progression by AKT1 inhibition–driven immune activation

    doi: 10.1038/s41598-026-45621-y

    Figure Lengend Snippet: Urolithin A suppresses CRC cell proliferation and enhances T-cell activation. (A) Dose–response curves of UA in HCT15, HCT116, MC38, NCM460 and MCEC cells at 48 h and 72 h, with corresponding IC 50 values. The selectivity index (SI = IC 50 normal / IC 50 cancer) is shown for each cell line; (B-C) Effects of increasing concentrations of UA on the viability of CTLL-2 cells and human CD8 + T cells (hCD8 + T) at 48 h; (D) Schematic illustration of T-cell and tumor cell co-culture in the presence of UA; (E-G) Cell viability assays demonstrating that combined treatment with UA (20 or 25 µM) and T cells more effectively suppresses the proliferation of HCT15, HCT116, and MC38 cells compared with UA or T-cell treatment alone; (H) Western blot analysis showing the effects of UA (15, 20 or 25 µM) on the phosphorylation levels of AKT and mTOR in HCT15, HCT116, and MC38 cells, as well as the regulation of p-FOXO1, TCF1, GZMB, and p-AKT in hCD8⁺ T cells and CTLL-2 cells. P < 0.05 was considered statistically significant (* P < 0.05, ** P < 0.01, *** P < 0.001).

    Article Snippet: Cell lines The colorectal cancer cell lines HCT15, HCT116, and MC38; the colonic epithelial cell line NCM460; and the human and murine lymphocyte cell lines CTLL-2 were obtained from Procell (Wuhan, China), while the murine colonic epithelial cell line MCEC was purchased from the ATCC cell bank.

    Techniques: Activation Assay, Co-Culture Assay, Western Blot, Phospho-proteomics

    Urolithin A suppresses CRC proliferation, migration, invasion, and enhances CD8⁺ T-cell infiltration. (A–B) Wound-healing assays and quantification showing that UA(20 μm) combined with lymphocytes (hCD8 + T cells or CTLL-2) markedly inhibits migration of HCT15, HCT116, and MC38 cells at 24 h and 48 h; (C–D) Transwell invasion and migration assays and quantification indicating that UA (20 μm) together with lymphocytes significantly reduces invasion index of HCT15, HCT116, and MC38 cells; (E)Schematic diagram of the MC38 orthotopic colorectal cancer mouse model and treatment regimen with UA (100 mg/kg/day); (F–G) Representative macroscopic images and tumor volume measurements demonstrating that UA treatment inhibits tumor growth; (H) Representative H&E staining of tumors from vehicle- and UA-treated mice; (I) Immunohistochemical staining of Ki67 showing decreased proliferation in UA-treated tumors; (J) Immunohistochemical staining of CD8 revealing enhanced CD8⁺ T-cell infiltration in UA-treated tumors; (K) Quantitative analysis showing that UA lowers the proliferation index and increases CD8⁺ T-cell infiltration in vivo . P < 0.05 was considered statistically significant (* P < 0.05, ** P < 0.01, *** P < 0.001).

    Journal: Scientific Reports

    Article Title: Urolithin A blocks colorectal cancer progression by AKT1 inhibition–driven immune activation

    doi: 10.1038/s41598-026-45621-y

    Figure Lengend Snippet: Urolithin A suppresses CRC proliferation, migration, invasion, and enhances CD8⁺ T-cell infiltration. (A–B) Wound-healing assays and quantification showing that UA(20 μm) combined with lymphocytes (hCD8 + T cells or CTLL-2) markedly inhibits migration of HCT15, HCT116, and MC38 cells at 24 h and 48 h; (C–D) Transwell invasion and migration assays and quantification indicating that UA (20 μm) together with lymphocytes significantly reduces invasion index of HCT15, HCT116, and MC38 cells; (E)Schematic diagram of the MC38 orthotopic colorectal cancer mouse model and treatment regimen with UA (100 mg/kg/day); (F–G) Representative macroscopic images and tumor volume measurements demonstrating that UA treatment inhibits tumor growth; (H) Representative H&E staining of tumors from vehicle- and UA-treated mice; (I) Immunohistochemical staining of Ki67 showing decreased proliferation in UA-treated tumors; (J) Immunohistochemical staining of CD8 revealing enhanced CD8⁺ T-cell infiltration in UA-treated tumors; (K) Quantitative analysis showing that UA lowers the proliferation index and increases CD8⁺ T-cell infiltration in vivo . P < 0.05 was considered statistically significant (* P < 0.05, ** P < 0.01, *** P < 0.001).

    Article Snippet: Cell lines The colorectal cancer cell lines HCT15, HCT116, and MC38; the colonic epithelial cell line NCM460; and the human and murine lymphocyte cell lines CTLL-2 were obtained from Procell (Wuhan, China), while the murine colonic epithelial cell line MCEC was purchased from the ATCC cell bank.

    Techniques: Migration, Staining, Immunohistochemical staining, In Vivo